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I need to answer all the following sections A , B ,C mention everything in un
I need to answer all the following sections A , B ,C mention everything in under the A , B ,C section Which means this (i) , (ii) ,(iii) ,(iv) , (v) which means each section have points that i need to include in my essay
Here is what is required :
(A)
Outline TWO unmet clinical needs that could be addressed by your technology.
Each of the following points should be covered and explained clearly, concisely and accurately to give a balanced and informative overview of the clinical need:
(i)
Inclusion of two distinct appropriate examples of unmet clinical need. These could be diseases or another need that the technology could be applied to, eg better diagnostics. Dependent on the technology, a specific disease (eg cystic fibrosis or a broad disease class (eg solid tumors) could be chosen.
(ii)
Explanation of disease aetiology, including appropriate molecular detail eg gene names.
(iii)
Explanation of disease progression and consequences, with statistics where relevant.
(iv)
Discussion of epidemiology in UK and internationally, with indication of disease burden and scale of clinical need, and statistics where relevant.
(v)
Explanation of current therapeutic approaches and discussion of their limitations. Depending on the disease, these could vary from no current curative treatment to a range of good therapies that could still be improved due to unpleasant side effects or poor compliance.
(B)
Describe how distinct technologies within your chosen technology area could be used to address these needs.
Clear explanation of how approaches from within the technology area could be applied to each unmet clinical need. For a 2:1 or above, students should cover distinct approaches for each clinical need (eg siRNA and CRISPR, or microneedles and 3D printing). The following points should be addressed:
Explanation of how the technology works. This should include a clear and accurate summary of how this specific technological approach would be used to treat this specific clinical need, with appropriate mechanistic detail, but
(i)
should be concise and focused on the topic being addressed.
(ii)
Explain any variables in how this approach could be applied to this clinical need, for example delivery method or specific design choices (eg ASO modification), and which of these variables is most suitable/promising, with rationale for this choice. If several approaches are promising you can summarise this and explain why.
(iii)
Give an accurate overview of clinical research and development to date.
Depending on the level of research this does not need to cover everything that fias been done, but should summarise the main approaches taken, the stage of development (eg pre-clinical, or specific clinical trial stage) and give an accurate overview of how successful this approach has been in research to date, with statistics if appropriate.
(C)
Describe the barriers to clinical adoption of your chosen technology for each of these needs.
Balanced and critical overview of the likelihood of each of the chosen technological approaches becoming a useful approach to each clinical need in future. Exactly what is covered here will be very individual to the topic, and students should use their judgment to discuss the barriers that are relevant to the specific topics they have covered. As a general guideline, this answer should include:
(i)
Consideration of any relevant barriers to your approach being used in clinical practice. These may include the practicalities of development and production, delivery, efficacy, cost, ethics, as possible examples, but the relevant barriers will be very specific to an individual approach. Discussion of generic barriers that are not relevant to this particular application will be marked down.
(ii)
Discussion of any alternative approaches to the clinical keed that are also undergoing research or development and how these may influence the adoption of your chosen technological approach, where relevant.
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